{"product_id":"agammaglobulinemia-panel-por-exoma-clinico-sec-cnvs-27-genes","title":"AGAMMAGLOBULINEMIA: CLINICAL EXOME PANEL (Sec. \u0026amp; CNVs) – 27 genes","description":"\u003cp\u003eThe Agammaglobulinemia Panel studies 27 genes associated with developmental and signaling defects in B lymphocytes that result in profound hypogammaglobulinemia, recurrent sinopulmonary infections, chronic diarrhea, and poor vaccine response. Using next-generation sequencing (NGS) (SNVs, indels, and CNVs), it investigates alterations in pre-B cell receptor\/BCR pathways, heavy\/light chain assembly, glycosylation, and PI3K–NF-κB pathways that lead to bone marrow maturation block or peripheral B cell dysfunction. Some of the genes included in this panel are: BTK, BLNK, CD19, CD79A, CD79B, CD81, TCF3, PIK3CD, PIK3R1, SH2D1A, GATA2, DNMT3B, LIG1, MOGS, and ZBTB24, among others. The complete list of genes can be obtained by contacting Genotica.\u003c\/p\u003e","brand":"LabGenetics","offers":[{"title":"Default Title","offer_id":52131418341642,"sku":null,"price":850.0,"currency_code":"EUR","in_stock":true}],"url":"https:\/\/www.genotica.com\/en\/products\/agammaglobulinemia-panel-por-exoma-clinico-sec-cnvs-27-genes","provider":"Genotica","version":"1.0","type":"link"}