LUNG ADENOCARCINOMA: SANGER SEQUENCING OF THE BRAF GENE
LabGenetics
Delivery time
4-6 weeks
Sample
Biopsy tissue
BRAF gene analysis using Sanger sequencing allows for the identification of somatic mutations associated with lung adenocarcinoma, particularly the V600E mutation, which abnormally activates the MAPK/ERK pathway, promoting cell proliferation. This study has significant clinical relevance, as the detection of BRAF mutations guides targeted therapies with BRAF and MEK inhibitors, personalizing treatment and improving prognosis. Furthermore, this analysis is crucial in tumors that are negative for EGFR, ALK, or ROS1, within the comprehensive diagnostic approach for non-small cell lung cancer.