HEPATIC ADENOMA: SANGER SEQUENCING OF THE HNF1A GENE (TCF1)
LabGenetics
Delivery time
3-4 weeks
Sample
Blood
Analysis of the HNF1A gene (also known as TCF1) using Sanger sequencing is indicated in patients with hepatic adenomas to identify somatic or germline mutations associated with this benign liver neoplasm. HNF1A variants are associated with a specific adenoma subtype characterized by intratumoral fat accumulation, a low risk of malignant transformation, and, in some cases, MODY3 diabetes when the mutation is germline. This study allows for precise molecular classification of the tumor, differentiation from other subtypes, and guidance for treatment and follow-up.